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ARTICLES IN INTERNATIONAL PEER-REVIEWED JOURNALS

PUBLICATIONS: About Me

1970 - 1980

  • Acar, J. F., Courvalin, P., and Chabbert, Y. A. 1970. Methicillin-resistant staphylococcemia: bacteriological failure of treatment with cephalosporins. Antimicrob. Agents Chemother. 280-285.

  • Courvalin, P., Carlier, C., and Chabbert, Y. A. 1972. Plasmid-linked tetracycline and erythromycin resistance in group D "Streptococcus". Ann. Inst. Pasteur 123: 755-759.

  • Courvalin, P., Carlier, C., Croissant, O., and Blangy, D. 1974. Identification of two plasmids determining resistance to tetracycline and to erythromycin in group D Streptococcus. Mol. Gen. Genet. 132: 181-192.

  • Courvalin, P., Weisblum, B., and Davies, J. 1977. Aminoglycoside-modifying enzyme of an antibiotic-producing bacterium acts as a determinant of antibiotic resistance in Escherichia coli. Proc. Natl. Acad. Sci. USA 74: 999-1003.

  • Courvalin, P., and Davies, J. 1977. Plasmid-mediated aminoglycoside phosphotransferase of broad substrate range that phosphorylates amikacin. Antimicrob. Agents Chemother. 11: 619-624.

  • Courvalin, P., Shaw, W. V., and Jacob, A. E. 1978. Plasmid-mediated mechanisms of resistance to aminoglycoside-aminocyclitol antibiotics and to chloramphenicol in group D streptococci. Antimicrob. Agents Chemother. 13: 716-725.

PUBLICATIONS: About Me

1980 - 1990

  • Courvalin, P., and M. Fiandt. 1980. Aminoglycoside-modifying enzymes of Staphylococcus aureus: Expression in Escherichia coli. Gene 9: 247-269.

  • Courvalin, P., C. Carlier, and E. Collatz. 1980. Plasmid-mediated resistance to aminocyclitol antibiotics in group D streptococci. J. Bacteriol. 143: 541-551.

  • Labigne-Roussel, A., G. Gerbaud, and P. Courvalin. 1981. Translocation of sequences encoding antibiotic resistance from the chromosome to a receptor plasmid in Salmonella ordonez. Mol. Gen. Genet. 182: 390-408.

  • Riou, J.Y., M. Guibourdenche, and P. Courvalin. 1981. Disk agar diffusion antibiotic susceptibility testing of Neisseria gonorrhoeae. Ann. Microb. (Institut Pasteur) 132B: 23-39.

  • Ounissi, H. and P. Courvalin. 1981. Classification of Macrolide-Lincosamide- Streptogramin-B-type antibiotic resistance determinants. Ann. Microbiol. (Institut Pasteur) 132B: 441-454.

  • Carlier, C., and P. Courvalin. 1982. A plasmid which does not encode the aminoglycoside phosphotransferase in the butirosin-producing strain of Bacillus circulans. J. Antibiotics 35: 629-634.

  • Labigne-Roussel, A., J.L. Witchitz, and P. Courvalin. 1982. Modular evolution of disseminated Inc 7-M plasmids encoding gentamicin resistance. Plasmid 8: 215-231.

  • Combes, T., C. Carlier, and P. Courvalin. 1983. Aminoglycoside-modifying enzyme content of a multiply resistant strain of Streptococcus faecalis. J. Antimicrob. Chemother. 11: 41-47.

  • Labigne-Roussel, A., S. Briaux-Gerbaud, and P. Courvalin. 1983. Tn1525, a kanamycin R determinant flanked by two direct copies of IS15. Mol. Gen. Genet. 189: 90-101.

  • Labigne-Roussel, A., and P. Courvalin. 1983. IS15, a new insertion sequence widely spread in R plasmids of Gram-negative bacteria. Mol. Gen. Genet. 189: 102-112.

  • Goldstein, F.W., A. Labigne-Roussel, G. Gerbaud, C. Carlier, E. Collatz, and P. Courvalin. 1983. Transferable plasmid-mediated antibiotic resistance in Acinetobacter. Plasmid 10: 138-147.

  • Trieu-Cuot, P., and P. Courvalin. 1983. Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5"-aminoglycoside phosphotransferase type III. Gene 23: 331-341.

  • Trieu-Cuot, P., A. Labigne-Roussel, and P. Courvalin. 1983. An IS15 insertion generates an eight base pair duplication of the target DNA. Gene 24: 125-129.

  • Collatz, E., C. Carlier, and P. Courvalin. 1983. The chromosomal 3'5"-aminoglycoside phosphotransferase in Streptococcus pneumoniae is closely related to its plasmid-coded homologues in Streptococcus faecalis and Staphylococcus aureus. J. Bacteriol. 156: 1373-1377.

  • Collatz, E., C. Carlier, and P. Courvalin. 1984. Characterization of high-level aminoglycoside resistance in a strain of Streptococcus pneumoniae. J. Gen. Microbiol. 130: 1665-1671.

  • Trieu-Cuot, P., and P. Courvalin. 1984. Nucleotide sequence of the transposable element IS15. Gene 30: 113-120.

  • Barthélémy, P., D. Autissier, G. Gerbaud, and P. Courvalin. 1984. Enzymic hydrolysis of erythromycin by a strain of Escherichia coli: a new mechanism of resistance. J. Antibiotics 37: 1692-1696.

  • Trieu-Cuot, P., A. Klier, and P. Courvalin. 1985. DNA sequences specifying the transcription of the streptococcal kanamycin resistance gene in Escherichia coli and in Bacillus subtilis. Mol. Gen. Genet. 198: 348-352.

  • Ounissi, H., and P. Courvalin. 1985. Nucleotide sequence of the gene ereA encoding the erythromycin esterase in Escherichia coli. Gene 35: 271-278.

  • Trieu-Cuot, P., and P. Courvalin. 1985. Transposition behavior of IS15 and its progenitor IS15-∆: are cointegrates exclusive end-products? Plasmid 14: 80-89.

  • Andremont, A., G. Gerbaud, C. Tancrede, and P. Courvalin. 1985. Plasmid-mediated susceptibility to intestinal microbial antagonisms in Escherichia coli. Infect. Immun.  49: 751-755.

  • Leclercq, R., C. Carlier, J. Duval, and P. Courvalin. 1985. Plasmid-mediated resistance to lincomycin by inactivation in Staphylococcus haemolyticus. Antimicrob. Agents Chemother. 28: 421-424.

  • Lambert, T., G. Gerbaud, P. Trieu-Cuot, and P. Courvalin. 1985. Structural relationship between the genes encoding 3'-aminoglycoside phosphotransferases in Campylobacter and in Gram-positive cocci. Ann. Microbiol. (Institut Pasteur) 136B: 135-150.

  • Gerbaud, G., A. Dodin, F. Goldstein, and P. Courvalin. 1985. Genetic basis of trimethoprim and 0/129 cross resistance in Vibrio cholerae. Ann. Microbiol. (Institut Pasteur) 136B: 265-273.

  • Trieu-Cuot, P., G. Gerbaud, T. Lambert, and P. Courvalin. 1985. In vivo transfer of genetic information between Gram-positive and Gram-negative bacteria. EMBO J. 4: 3583-3587.

  • Andremont, A., G. Gerbaud, and P. Courvalin. 1986. Plasmid-mediated high-level resistance to erythromycin in Escherichia coli. Antimicrob. Agents Chemother. 29: 515-518.

  • Arthur, M., A. Andremont, and P. Courvalin. 1986. Heterogeneity of genes conferring high-level resistance to erythromycin by inactivation in enterobacteria. Ann. Microbiol. (Institut Pasteur) 137A: 125-134.

  • Goldstein, F., G. Gerbaud, and P. Courvalin. 1986. Transposable resistance to trimethoprim and 0/129 in Vibrio cholerae. J. Antimicrob. Chemother. 17: 559-569.

  • Chaslus-Dancla, E., J.L. Martel, C. Carlier, J.P. Lafont, and P. Courvalin. 1986. Emergence of 3-N-acetyltransferase IV in Escherichia coli and Salmonella typhimurium isolated from animals in France. Antimicrob. Agents Chemother. 29: 239- 243.

  • Chaslus-Dancla, E., G. Gerbaud, J.P. Lafont, J.L. Martel, and P. Courvalin. 1986. Nucleic acid hybridization with a probe specific for 3-aminoglycoside acetyltransferase type IV: a survey of resistance to apramycin and gentamicin in animal strains of Escherichia coli. FEMS Microbiol. Lett. 34: 265-268.

  • Papadopoulou, B., G. Gerbaud, P. Courvalin, J.F. Acar, and F.W. Goldstein. 1986. Molecular epidemiology of resistance to trimethoprim in enterobacteria isolated in a Parisian hospital. Ann. Microbiol. (Institut Pasteur) 137A: 239-251.

  • Ferretti, J.J., K.S. Gilmore, and P. Courvalin. 1986. Nucleotide sequence analysis of the bifunctional 6'-aminoglycoside acetyltransferase, 2"-aminoglycoside phospho- transferase determinant from Streptococcus faecalis: identification and cloning of gene regions specifying the two activities. J. Bacteriol. 167: 631-638.

  • Brisson-Noël, A., and P. Courvalin. 1986. Nucleotide sequence of the gene linA encoding resistance to lincosamides in Staphylococcus haemolyticus. Gene 43 : 247- 253.

  • Arthur, M., and P. Courvalin. 1986. Contribution of two different mechanisms to erythromycin resistance in Escherichia coli. Antimicrob. Agents Chemother. 30: 694- 700.

  • Arthur, M., A. Andremont, and P. Courvalin. 1987. Distribution of erythromycin esterases and RNA methylase genes in members of the family Enterobacteriaceae highly resistant to erythromycin. Antimicrob. Agents Chemother. 31: 404-409.

  • Arthur, M., D. Autissier, and P. Courvalin. 1986. Analysis of the nucleotide sequence of the ereB gene encoding the erythromycin esterase type II. Nucl. Acids Res. 14: 4987-4999.

  • Lambert, T., F. Megraud, G. Gerbaud, and P. Courvalin. 1986. Susceptibility of Campylobacter pyloridis to 20 antimicrobial agents. Antimicrob. Agents Chemother. 30: 510-511.

  • Martin, P., P. Trieu-Cuot, and P. Courvalin. 1986. Nucleotide sequence of the tetM tetracycline resistance determinant of the streptococcal conjugative shuttle transposon Tn1545. Nucleic Acids Res. 14: 7047-7058.

  • Courvalin, P., and C. Carlier. 1986. Transposable multiple antibiotic resistance in Streptococcus pneumoniae. Mol. Gen. Genet. 205: 291-297.

  • Courvalin, P., and C. Carlier. 1987. Tn1545: A conjugative shuttle transposon. Mol. Gen. Genet. 206: 259-264.

  • Caillaud, F., C. Carlier, and P. Courvalin. 1987. Physical analysis of the conjugative shuttle transposon Tn1545. Plasmid 17: 58-60.

  • Caillaud, F., and P. Courvalin. 1987. Nucleotide sequence of the ends of the conjugative shuttle transposon Tn1545. Mol. Gen. Genet. 209: 110-115.

  • Chaslus-Dancla, E., G. Gerbaud, M. Lagorce, J.P. Lafont, and P. Courvalin. 1987. Persistence of an antibiotic resistance plasmid in intestinal Escherichia coli of chickens in the absence of selective pressure. Antimicrob. Agents Chemother. 31: 784-788.

  • Caillaud, F., P. Trieu-Cuot, C. Carlier, and P. Courvalin. 1987. Nucleotide sequence of the kanamycin resistance determinant of the pneumococcal transposon Tn1545: Evolutionary relationships and transcriptional analysis of aphA-3 genes. Mol. Gen. Genet. 207: 509-513.

  • Sirot, D., J. Sirot, R. Labia, P. Courvalin, A. Darfeuille-Michaud, R. Perroux, and R. Cluzel. 1987. Transferable resistance to third generation cephalosporins in clinical isolates of Klebsiella pneumoniae: Identification of CTX-1, a novel beta-lactamase. J. Antimicrob. Chemother. 20: 323-334.

  • Ouellette, M., G. Gerbaud, T. Lambert, and P. Courvalin. 1987. Acquisition by a Campylobacter-like strain of aphA-1, a kanamycin resistance determinant from members of the family Enterobacteriaceae. Antimicrob. Agents Chemother. 31: 1021- 1026.

  • Chaslus-Dancla, E., G. Gerbaud, J.L. Martel, M. Lagorce, J.P. Lafont, and P. Courvalin. 1987. Detection of a second mechanism of resistance to gentamicin in animal strains of Escherichia coli. Antimicrob. Agents Chemother. 31: 1274-1277.

  • Chaslus-Dancla, E., G. Gerbaud, M. Lagorce, J.L. Martel, J.P. Lafont, and P. Courvalin. 1987. Probable transmission between animals of a plasmid encoding aminoglycoside 3- N-acetyltransferase IV and dihydrofolate reductase I. Vet. Microbiol. 15: 97-104.

  • Leclercq, R., A. Brisson-Noël, J. Duval, and P. Courvalin. 1987. Phenotypic expression and genetic heterogeneity of lincosamide inactivation in Staphylococcus spp. Antimicrob. Agents Chemother. 31: 1887-1891.

  • Trieu-Cuot, P., C. Carlier, P. Martin, and P. Courvalin. 1987. Plasmid transfer by conjugation from Escherichia coli to Gram-positive bacteria. FEMS Microbiol. Lett. 48:289-294 

  • Sougakoff, W., B. Papadopoulou, P. Nordmann, and P. Courvalin. 1987. Nucleotide sequence and distribution of gene tetO encoding tetracycline resistance in Campylobacter coli. FEMS Microbiol. Lett. 44: 153-159.

  • Lambert, T., G. Gerbaud, and P. Courvalin. 1988. Transferable amikacin resistance in Acinetobacter due to a new type of 3'-aminoglycoside phosphotransferase. Antimicrob. Agents Chemother. 32: 15-19.

  • Ouellette, M., G. Gerbaud, and P. Courvalin. 1988. Genetic, biochemical, and molecular characterization of strains of Vibrio cholerae multiresistant to antibiotics. Ann. Microbiol. (Institut Pasteur) 139: 105-113.

  • Brisson-Noël, A., M. Arthur, and P. Courvalin. 1988. Evidence for natural gene transfer from gram-positive cocci to Escherichia coli. J. Bacteriol. 170: 1739-1745.

  • Storrs, M.J., P. Courvalin, and T.J. Foster. 1988. Genetic analysis of gentamicin resistance in methicillin and gentamicin resistant strains of Staphylococcus aureus isolated in Dublin hospitals. Antimicrob. Agents Chemother. 32: 1174-1181.

  • Sougakoff, W., S. Goussard, G. Gerbaud, and P. Courvalin. 1988. Plasmid-mediated resistance to third-generation cephalosporins caused by point-mutations in TEM-type penicillinase genes. Rev. Infect. Dis. 10: 879-884.

  • Papadopoulou, B., and P. Courvalin. 1988. Dispersal in Campylobacter of aphA-3, a kanamycin resistance determinant from gram-positive cocci. Antimicrob. Agents Chemother. 32: 945-948.

  • Zilhao, R., B. Papadopoulou, and P. Courvalin. 1988. Occurrence of the Campylobacter resistance gene tetO in Enterococcus and Streptococcus spp. Antimicrob. Agents Chemother. 32 : 1793-1796.

  • Brisson-Noël, A., P. Delrieu, D. Samain, and P. Courvalin. 1988. Inactivation of lincosaminide antibiotics in Staphylococcus: identification of lincosaminide 0- nucleotidyltransferases and comparison of the corresponding resistance genes. J. Biol. Chem. 263: 15880-15887.

  • Trieu-Cuot, P., C. Carlier, and P. Courvalin. 1988. Conjugative plasmid transfer from Enterococcus faecalis to Escherichia coli. J. Bacteriol. 170 : 4388-4391.

  • Martin, P., E. Jullien, and P. Courvalin. 1988. Nucleotide sequence of Acinetobacter baumannii aphA-6 gene: Evolutionary and functional implications of sequence homologies with nucleotide-binding proteins, kinases and other aminoglycoside-modifying enzymes. Mol. Microbiol. 2: 615-625.

  • Leclercq, R., E. Derlot, J. Duval, and P. Courvalin. 1988. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N. Engl. J. Med. 319: 157- 161.

  • Sakamoto, H., R. Zilhao, R. Bismuth, P. Courvalin, and J.L. Guesdon. 1988. Non-radioactive gene probes for the detection of tetracycline resistance in staphylococci. Mol. Cell. Probes 2: 321-330.

  • Sougakoff, W., S. Goussard, and P. Courvalin. 1988. The TEM-3 ß-lactamase, which hydrolyzes broad-spectrum cephalosporins, is derived from the TEM-2 penicillinase by two amino-acid substitutions. FEMS Microbiol. Lett. 56: 343-348.

  • Taylor, D.E., W. Yan, L.K. Ng, E.K. Manavathu, and P. Courvalin. 1989. Genetic characterization of kanamycin resistance in Campylobacter coli. Ann. Microbiol. (Institut Pasteur) 139: 665-676.

  • Mabilat, C., and P. Courvalin. 1989. Gene heterogeneity for resistance to macrolides, lincosamides and streptogramins in Enterobacteriaceae. Ann. Microbiol. (Institut Pasteur) 139: 677-681.

  • Leclercq, R., E. Derlot, M. Weber, J. Duval, and P. Courvalin. 1989. Transferable vancomycin and teicoplanin resistance in Enterococcus faecium. Antimicrob. Agents Chemother. 33: 10-15.

  • Sougakoff, W., A. Petit, S. Goussard, D. Sirot, A. Buré, and P. Courvalin. 1989. Characterization of the plasmid genes blaT-4 and blaT-5 which encode the broad spectrum ß-lactamases TEM-4 and TEM-5 in Enterobacteriaceae. Gene 78: 339-348.

  • Poyart-Salmeron, C., P. Trieu-Cuot, C. Carlier, and P. Courvalin. 1989. Molecular characterization of two proteins involved in the excision of the pneumococcal transposon Tn1545: homologies with other site-specific recombinases. EMBO J. 8: 2425-2433.

  • Paul, G.C., G. Gerbaud, A. Buré, A.M. Philippon, B. Pangon, and P. Courvalin. 1989. TEM-4, a new plasmid-mediated ß-lactamase that hydrolyzes broad-spectrum cephalosporins in a clinical isolate of Escherichia coli. Antimicrob. Agents Chemother. 33: 1958-1963.

  • Chaslus-Dancla, E., J. Glupczynski, G. Gerbaud, M. Lagorce, J.P. Lafont, and P. Courvalin. 1989. Detection of apramycin resistant Enterobacteriaceae in hospital isolates. FEMS Microbiol. Lett. 61: 261-266.

  • Derlot, E., C. Poyart-Salmeron, and P. Courvalin. 1989. Antibacterial and plasmid curing activity of lomefloxacin in vitro. Eur. J. Clin. Microb. Infect. Dis. 8: 1048-1052.

  • Etienne, J., G. Gerbaud, P. Courvalin, and J. Fleurette. 1989. Plasmid-mediated resistance to fosfomycin in Staphylococcus epidermidis. FEMS Microbiol. Lett. 61: 133-138.

PUBLICATIONS: About Me

1990 - 2000

  • Petit, A., G. Gerbaud, D. Sirot, P. Courvalin, and J. Sirot. 1990. Molecular epidemiology of TEM-3 (CTX-1) ß-lactamase. Antimicrob. Agents Chemother. 34: 219-224.

  • Mabilat, C., S. Goussard, W. Sougakoff, R. C. Spencer, and P. Courvalin. 1990. Direct sequencing of the amplified structural gene and promoter for the extended-broad- spectrum ß-lactamase TEM-9 (RHH-1) of Klebsiella pneumoniae. Plasmid 23: 27-34.

  • Brisson-Noël, A., S. Dutka-Malen, C. Molinas, R. Leclercq, and P. Courvalin. 1990. Cloning and heterospecific expression of the resistance determinant vanA encoding high-level resistance to glycopeptides in Enterococcus faecium BM4147. Antimicrob. Agents Chemother. 34: 924-927.

  • Zilhao, R., and P. Courvalin. 1990. Nucleotide sequence of the fosB gene conferring fosfomycin resistance in Staphylococcus epidermidis. FEMS Microbiol. Lett. 68: 267- 272.

  • Tham, T.N., C. Mabilat, P. Courvalin, and J.L. Guesdon. 1990. Biotinylated oligonucleotide probes for the detection and the characterization of TEM-type extended broad spectrum ß-lactamases in Enterobacteriaceae. FEMS Microbiol. Lett. 69: 109- 116.

  • Lambert, T., G. Gerbaud, P. Bouvet, J.F. Vieu, and P. Courvalin. 1990. Dissemination of amikacin resistance gene aphA-6 in Acinetobacter spp. Antimicrob. Agents Chemother. 34: 1244-1248.

  • Pinto-Alphandary, H., C. Mabilat, and P. Courvalin. 1990. Emergence of aminoglycoside resistance genes aadA and aadE in the genus Campylobacter. Antimicrob. Agents Chemother. 34: 1294-1296.

  • Carlier, C., and P. Courvalin. 1990. Emergence of 4',4"-aminoglycoside nucleotidyltransferase in enterococci. Antimicrob. Agents Chemother. 34: 1565-1569.

  • Bismuth, R., R. Zilhao, H. Sakamoto, J.L. Guesdon, and P. Courvalin. 1990. Gene heterogeneity for tetracycline resistance in Staphylococcus spp. Antimicrob. Agents Chemother. 34: 1611-1614.

  • Dutka-Malen, S., R. Leclercq, V. Coutant, J. Duval, and P. Courvalin. 1990. Phenotypic and genotypic heterogeneity of glycopeptide resistance determinants in gram-positive bacteria. Antimicrob. Agents Chemother. 34: 1875-1879.

  • Dutka-Malen, S., C. Molinas, M. Arthur, and P. Courvalin. 1990. The VANA glycopeptide resistance protein is related to D-alanyl-D-alanine ligase cell wall biosynthesis enzymes. Mol. Gen. Genet. 224: 364-372.

  • Arthur, M., C. Molinas, C. Mabilat, and P. Courvalin. 1990. Detection of erythromycin resistance by the polymerase chain reaction using primers in conserved regions of erm rRNA methylase genes. Antimicrob. Agents Chemother. 34: 2024-2026.

  • Poyart-Salmeron, C., C. Carlier, P. Trieu-Cuot, A. Courtieu, and P. Courvalin. 1990. Transferable plasmid-mediated antibiotic resistance in Listeria monocytogenes. Lancet 335: 1422-1426.

  • Poyart-Salmeron, C., P. Trieu-Cuot, C. Carlier, and P. Courvalin. 1990. The integration-excision system of the streptococcal transposon Tn1545 is structurally and functionally related to those of lambdoïd phages. Mol. Microbiol. 4: 1513-1521.

  • Trieu-Cuot, P., C. Poyart-Salmeron, C. Carlier, and P. Courvalin. 1990. Nucleotide sequence of the erythromycin resistance gene of the conjugative transposon Tn1545. Nucleic Acids Res. 18: 3660.

  • Trieu-Cuot, P. , C. Carlier, C. Poyart-Salmeron, and P. Courvalin. 1990. A pair of mobilizable shuttle vectors conferring resistance to spectinomycin for molecular cloning in Escherichia coli and Gram-positive bacteria. Nucleic Acids Res. 18: 4296.

  • Ounissi, H., E. Derlot, C. Carlier, and P. Courvalin. 1990. Gene homogeneity for aminoglycoside-modifying enzymes in gram-positive cocci. Antimicrob. Agents Chemother. 34: 2164-2168.

  • Mabilat, C., and P. Courvalin. 1990. Development of "Oligotyping" for characterization and molecular epidemiology of TEM ß-lactamases in members of the family Enterobacteriaceae. Antimicrob. Agents Chemother. 34: 2210-2216.

  • Escande F., G. Gerbaud, J.L. Martel, and P. Courvalin. 1991. Resistance to trimethoprim and 2,4-diamino-6,7-diisopropyl-pteridine (0/129) in Pasteurella haemolytica. Vet. Microbiol. 26: 107-114.

  • Leclercq, R., E. Bingen, Q.H. Su, N. Lambert-Zechovski, P. Courvalin, and J. Duval. 1991. Effects of combinations of ß-lactams, daptomycin, gentamicin, and glycopeptides against glycopeptide-resistant enterococci. Antimicrob. Agents Chemother. 35: 92-98.

  • Doucet-Populaire, F., P. Trieu-Cuot, I. Dosbaa, A. Andremont, and P. Courvalin. 1991. Inducible transfer of conjugative transposon Tn1545 from Enterococcus faecalis to Listeria monocytogenes in the digestive tract of gnotobiotic mice. Antimicrob. Agents Chemother. 35: 185-187.

  • Goussard, S., W. Sougakoff, C. Mabilat, A. Bauernfeind, and P. Courvalin. 1991. An IS1-like element is responsible for high-level synthesis of extended-spectrum ß- lactamase TEM-6 in Enterobacteriaceae. J. Gen. Microbiol. 137: 2681-2687.

  • Archambaud, M., G. Gerbaud, E. Labau, N. Marty, and P. Courvalin. 1991. Possible in-vivo transfer of ß-lactamase TEM-3 from Klebsiella pneumoniae to Salmonella kedougou. J. Antimicrob. Chemother. 27: 427-436.

  • Vandenesh, F., M.J. Storrs, F. Poitevin-Later, J. Etienne, P. Courvalin, and J. Fleurette. 1991. -like haemolysin produced by Staphylococcus lugdunensis. FEMS Microbiol. Lett. 78: 65-68.

  • Arthur, M., C. Molinas, S. Dutka-Malen, and P. Courvalin. 1991. Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases. Gene 103: 133-134.

  • Storrs, M.J., C. Poyart-Salmeron, P. Trieu-Cuot, and P. Courvalin. 1991. Conjugative transposition of Tn916 requires the excisive and integrative activities of the transposon-encoded integrase. J. Bacteriol. 173: 4347-4352.

  • Bugg, T.D.H., S. Dutka-Malen, M. Arthur, P. Courvalin, and C.T. Walsh. 1991. Identification of vancomycin resistance protein VanA as a D-Alanine: D-Alanine ligase of altered substrate specificity. Biochemistry 30: 2017-2021.

  • Goussard, S., and P. Courvalin. 1991. Sequence of the genes blaT-1B and blaT-2. Gene 102: 71-73.

  • Trieu-Cuot, P., C. Carlier, C. Poyart-Salmeron, and P. Courvalin. 1991. Shuttle vectors containing a multiple cloning site and a lacZ〈gene for conjugal transfer of DNA from Escherichia coli to Gram-positive bacteria. Gene 102: 99-104.

  • Poyart-Salmeron, C., P. Trieu-Cuot, C. Carlier, and P. Courvalin. 1991. Nucleotide sequences specific for Tn1545-like conjugative transposons in pneumococci and staphylococci resistant to tetracycline. Antimicrob. Agents Chemother. 35: 1657-1660.

  • Trieu-Cuot, P., C. Carlier, C. Poyart-Salmeron, and P. Courvalin. 1991. An integrative vector exploiting the transposition properties of Tn1545 for insertional mutagenesis and cloning of genes from Gram-positive bacteria. Gene 106: 21-27.

  • Bugg, T.D.H., G.D. Wright, S. Dutka-Malen, M. Arthur, P. Courvalin, and C.T. Walsh. 1991. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry 30: 10408-10415.

  • Etienne, J., G. Gerbaud, J. Fleurette, and P. Courvalin. 1991. Characterization of staphylococcal plasmids hybridizing with the fosfomycin resistance gene fosB. FEMS Microbiol. Lett. 84: 119-122.

  • Poyart-Salmeron, C., P. Trieu-Cuot, C. Carlier, A. McGowan, J. McLauchlin, and P. Courvalin. 1992. Genetic basis of tetracycline resistance in clinical isolates of Listeria monocytogenes. Antimicrob. Agents Chemother. 36: 463-466.

  • Doucet-Populaire, F., P. Trieu-Cuot, A. Andremont, and P. Courvalin. 1992. Conjugal transfer of plasmid DNA from Enterococcus faecalis to Escherichia coli in digestive tracts of gnotobiotic mice. Antimicrob. Agents Chemother. 36: 502-504.

  • Arthur, M., C. Molinas, and P. Courvalin. 1992. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J. Bacteriol. 174: 2582-2591.

  • Arthur, M., C. Molinas, T.D.H. Bugg, G.D. Wright, C.T. Walsh, and P. Courvalin. 1992. Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci. Antimicrob. Agents Chemother. 36: 867-869.

  • Arthur, M., C. Molinas, and P. Courvalin. 1992. Sequence of the vanY gene required for production of a vancomycin-inducible D,D-carboxypeptidase in Enterococcus faecium BM4147. Gene 120: 111-114.

  • Wright, G.D., C. Molinas, M. Arthur, P. Courvalin, and C.T. Walsh. 1992. Characterization of VanY: a DD-carboxypeptidase from vancomycin resistant Enterococcus faecium BM4147. Antimicrob. Agents Chemother. 36: 1514-1518.

  • Dutka-Malen, S., C. Molinas, M. Arthur, and P. Courvalin. 1992. Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine-D-alanine ligase- related protein necessary for vancomycin resistance. Gene 112: 53-58.

  • Leclercq, R., S. Dutka-Malen, J. Duval, and P. Courvalin. 1992. The vancomycin resistance gene vanC is specific of Enterococcus gallinarum. Antimicrob. Agents Chemother. 36: 2005-2008.

  • Soussy, C.J., J.F. Acar, R. Cluzel, P. Courvalin, J. Duval, J. Fleurette, F. Mégraud, M. Meyran, and A. Thabaut. 1992. A collaborative study of the in-vitro sensitivity to RP 59500 of bacteria isolated in seven hospitals in France. J. Antimicrob. Chemother. 30, Suppl. A: 53-58.

  • Mabilat, C., J. Lourençao-Vital, S. Goussard, and P. Courvalin. 1992. A new example of physical linkage between Tn1 and Tn21: the antibiotic multiple-resistance region of plasmid pCFF04 encoding extended-spectrum ß-lactamase TEM-3. Mol. Gen. Genet. 235: 113-121.

  • Ménard, R., C. Molinas, M. Arthur, J. Duval, P. Courvalin, and R. Leclercq. 1993. Overproduction of 3'-aminoglycoside phosphotransferase type I confers resistance to tobramycin in Escherichia coli. Antimicrob. Agents Chemother. 37: 78-83.

  • Arthur, M., C. Molinas, F. Depardieu, and P. Courvalin. 1993. Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J. Bacteriol. 175: 117-127.

  • Evers, S., D.F. Sahm, and P. Courvalin. 1993. The vanB gene of vancomycin resistant Enterococcus faecalis V583 is structurally related to genes encoding D-Ala:D-Ala ligases and glycopeptide resistance proteins VanA and VanC. Gene 124: 143-144.

  • Quintiliani Jr., R., S. Evers, and P. Courvalin. 1993. The vanB gene confers various levels of self-transferable resistance to vancomycin in enterococci. J. Infect. Dis. 167: 1220-1223.

  • Trieu-Cuot, P., C. Poyart-Salmeron, C. Carlier, and P. Courvalin. 1993. Sequence requirements for target activity in site-specific recombination mediated by the Int protein of transposon Tn1545. Mol. Microbiol. 8: 179-185.

  • Trieu-Cuot, P., E. Derlot, and P. Courvalin. 1993. Enhanced conjugative transfer of plasmid DNA from Escherichia coli to Staphylococcus aureus and Listeria monocytogenes. FEMS Microbiol. Lett. 109: 19-24.

  • Galimand, M., T. Lambert, G. Gerbaud, and P. Courvalin. 1993. Characterization of the aac(6')-Ib gene encoding an aminoglycoside 6'-N-acetyltransferase in Pseudomonas aeruginosa BM2656. Antimicrob. Agents Chemother. 37: 1456-1462.

  • Lambert, T., G. Gerbaud, M. Galimand, and P. Courvalin. 1993. Characterization of Acinetobacter haemolyticus aac(6')-Ig gene encoding an aminoglycoside 6'-N- acetyltransferase which modifies amikacin. Antimicrob. Agents Chemother. 37: 2093- 2100.

  • Alos, J.I., T. Lambert, and P. Courvalin. 1993. Comparison of two molecular methods for tracing nosocomial transmission of Escherichia coli KI in a neonatal unit. J. Clin. Microbiol. 31: 1704-1709.

  • Charpentier, E., G. Gerbaud, and P. Courvalin. 1993. Characterization of a new class of tetracycline resistance gene tet (S) in Listeria monocytogenes BM4210. Gene 131: 27- 34.

  • Rende-Fournier, R., R. Leclercq, M. Galimand, J. Duval, and P. Courvalin. 1993. Identification of the satA gene encoding a streptogramin A acetyltransferase in Enterococcus faecium BM4145. Antimicrob. Agents Chemother. 37: 2119-2125.

  • Costa, Y., M. Galimand, R. Leclercq, J. Duval, and P. Courvalin. 1993. Characterization of the chromosomal aac(6')-Ii gene specific for Enterococcus faecium. Antimicrob. Agents Chemother. 37: 1896-1903.

  • Evers, S., P.E. Reynolds, and P. Courvalin. 1994. Sequence of the vanB and ddl genes encoding D-alanine:D-lactate and D-alanine:D-alanine ligases in vancomycin-resistant Enterococcus faecalis V583. Gene 140: 97-102.

  • Lambert, T., M.C. Ploy, and P. Courvalin. 1994. A spontaneous point mutation in the aac(6')-Ib' gene results in altered substrate specificity of aminoglycoside 6'-N- acetyltransferase of a Pseudomonas fluorescens strains. FEMS Microbiol. Lett. 115: 297-304.

  • Lambert, T., G. Gerbaud, and P. Courvalin. 1994. Characterization of transposon Tn1528, which confers amikacin resistance by synthesis of aminoglycoside 3'-O- phosphotransferase type VI. Antimicrob. Agents Chemother. 38: 702-706.

  • Tankovic, J., N. Desplaces, J. Duval, and P. Courvalin. 1994. In vivo selection during pefloxacin therapy of a mutant of Staphylococcus aureus with two mechanisms of fluoroquinolone resistance. Antimicrob. Agents Chemother. 38: 1149-1151.

  • Tankovic, J., J. Duval, and P. Courvalin. 1994. Construction of a gyrA plasmid for genetic characterization of fluoroquinolone-resistant Staphylococcus aureus. FEMS Immunol. Med. Microbiol. 9: 35-40.

  • Dutka-Malen, S., B. Blaimont, G. Wauters, and P. Courvalin. 1994. Emergence of high- level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus. Antimicrob. Agents Chemother. 38: 1675-1677.

  • Reynolds, P.E., F. Depardieu, S. Dutka-Malen, M. Arthur, and P. Courvalin. 1994. Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine. Mol. Microbiol. 13: 1065- 1070.

  • Arthur, M., F. Depardieu, H.A. Snaith, P.E. Reynolds, and P. Courvalin. 1994. Contribution of VanY D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors. Antimicrob. Agents Chemother. 38: 1899-1903.

  • Navarro, F., and P. Courvalin. 1994. Analysis of genes encoding D-alanine:D-alanine ligase- related enzymes in Enterococcus casseliflavus and Enterococcus flavescens. Antimicrob. Agents Chemother. 38: 1788-1793.

  • Jacob, J., S. Evers, K. Bischoff, C. Carlier, and P. Courvalin. 1994. Characterization of the sat4 gene encoding a streptothricin acetyltransferase in Campylobacter coli BE/G4. FEMS Microbiol. Lett. 120: 13-18.

  • Charpentier, E., G. Gerbaud, and P. Courvalin. 1994. Presence of the Listeria tetracycline resistance gene tet(S) in Enterococcus faecalis. Antimicrob. Agents Chemother. 38: 2330-2335.

  • Lambert, T., G. Gerbaud, and P. Courvalin. 1994. Characterization of the chromosomal aac(6')-Ij gene of Acinetobacter sp. 13 and the aac(6')-Ih plasmid gene of Acinetobacter baumannii. Antimicrob. Agents Chemother. 38 : 1883-1889.

  • Quintiliani Jr., R., and P. Courvalin. 1994. Conjugal transfer of the vancomycin resistance determinant vanB between enterococci involves the movement of large genetic elements from chromosome to chromosome. FEMS Microbiol. Lett. 119: 359- 364.

  • Reynolds, P.E., H.A. Snaith, A.J. Maguire, S. Dutka-Malen, and P. Courvalin. 1994. Analysis of peptidoglycan precursors in vancomycin-resistant Enterococcus gallinarum BM4174. Biochem. J. 301: 5-8.

  • Meziane-Cherif, D., M.A. Badet-Denisot, S. Evers, P. Courvalin, and B. Badet. 1994. Purification and characterization of the VanB ligase associated with type B vancomycin resistance in Enterococcus faecalis V583. FEBS Lett. 354: 140-142.

  • Rudant, E., P. Bourlioux, P. Courvalin, and T. Lambert. 1994. Characterization of the

  • aac(6')-Ik gene of Acinetobacter sp. 6. FEMS Microbiol. Lett. 124 : 49-54.

  • Ploy, M.C., H. Giamarellou, P. Bourlioux, P. Courvalin, and T. Lambert. 1994. Detection of aac(6')-I genes in amikacin-resistant Acinetobacter spp. by PCR. Antimicrob. Agents Chemother. 38: 2925-2928.

  • Raquet, X., J. Lamotte-Brasseur, E. Fonzé, S. Goussard, P. Courvalin, and J.M. Frère. 1994. TEM ß-lactamase mutants hydrolysing third-generation cephalosporins: a kinetic and molecular modelling analysis. J. Mol. Biol. 244: 625-639.

  • Elisha, B.G., and P. Courvalin. 1995. Analysis of genes encoding D-alanine:D-alanine ligase related enzymes in Leuconostoc mesenteroides and Lactobacilli spp. Gene 152: 79-83.

  • Dutka-Malen, S., S. Evers, and P. Courvalin. 1995. Detection of glycopeptide resistance genotypes and identification to the species level of clinically relevant enterococci by PCR. J. Clin. Microbiol. 33: 24-27.

  • Dutka-Malen, S., M. Charles, and P. Courvalin. 1995. Evaluation of the BBL® Crystalâ„¢ MRSA ID system for rapid detection of methicillin resistance in Staphylococcus aureus. Clin. Microb. Infect. 1: 50-53.

  • Arthur, M., F. Depardieu, C. Molinas, P. Reynolds, and P. Courvalin. 1995. The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin. Gene 154: 87-92.

  • Charpentier, E., G. Gerbaud, C. Jacquet, J. Rocourt, and P. Courvalin. 1995. Incidence of antibiotic resistance in Listeria species. J. Infect. Dis. 172: 277-281.

  • Raquet, X., M. Vanhove, J. Lamotte-Brasseur, S. Goussard, P. Courvalin, and J.M. Frère. 1995. Stability of TEM ß-lactamase mutants hydrolyzing third generation cephalosporins. Proteins 23: 63-72.

  • Courvalin, P., S. Goussard, and C. Grillot-Courvalin. 1995 Gene transfer from bacteria to mammalian cells. C.R. Acad. Sci. Ser. III. 318: 1207-1212.

  • Evers, S., and P. Courvalin. 1996. Regulation of VanB-type vancomycin resistance gene expression by the VanSB-VanRB two-component regulatory system in Enterococcus faecalis V583. J. Bacteriol. 178: 1302-1309.

  • Nicolau, D.P., M.N. Marangos, C.H. Nightingale, K.B. Patel, B.W. Cooper, R. Quintiliani Jr., P. Courvalin, and R. Quintiliani. 1996. Efficacy of vancomycin and teicoplanin alone and in combination with streptomycin in experimental, low-level vancomycin-resistant, VanB-type Enterococcus faecalis endocarditis. Antimicrob. Agents Chemother. 40: 55-60.

  • Quintiliani Jr., R., and P. Courvalin. 1996. Characterization of Tn1547, a composite transposon flanked by the IS16 and IS256-like elements, that confers vancomycin resistance in Enterococcus faecalis BM4281. Gene 172: 1-8.

  • Arthur, M., F. Depardieu, P. Reynolds, and P. Courvalin. 1996. Quantitative analysis of the metabolism of soluble cytoplasmic peptidoglycan precursors of glycopeptide-resistant enterococci. Mol. Microbiol. 21: 33-44.

  • Evers, S., B. Casadewall, M. Charles, S. Dutka-Malen, M. Galimand, and P. Courvalin. 1996. Evolution of structure and substrate specificity in D-Alanine: D-Alanine ligases and related enzymes. J. Mol. Evol. 42: 706-712.

  • Tankovic, J., B. Périchon, J. Duval, and P. Courvalin. 1996. Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro. Antimicrob. Agents Chemother. 40: 2505- 2510.

  • Baptista, M., F. Depardieu, P. Courvalin, and M. Arthur. 1996. Specificity of induction of glycopeptide resistance genes in Enterococcus faecalis. Antimicrob. Agents Chemother. 40: 2291-2295.

  • Tankovic, J., F. Mahjoubi, P. Courvalin, J. Duval, and R. Leclercq. 1996. Development of fluoroquinolone resistance in Enterococcus faecalis and role of mutations in the DNA gyrase gyrA gene. Antimicrob. Agents Chemother. 40: 2558-2561.

  • Gootz, T.D., R. Zaniewski, S. Haskell, B. Schmieder, J. Tankovic, P. Courvalin, D. Girard, and R.J. Polzer. 1996. Activity of the new fluoroquinolone trovafloxacin (CP- 99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob. Agents Chemother. 40: 2691-2697.

  • Arthur, M., F. Depardieu, G. Gerbaud, M. Galimand, R. Leclercq, and P. Courvalin. 1997. The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction. J. Bacteriol. 179: 97-106.

  • Aslangul, E., M. Baptista, B. Fantin, F. Depardieu, M. Arthur, P. Courvalin, and C. Carbon. 1997. Selection of glycopeptide-resistant mutants of VanB-type Enterococcus faecalis BM4281 in vitro and in experimental endocarditis. J. Infect. Dis.175: 598-605.

  • Lynch, C., P. Courvalin, and H. Nikaido. 1997. Active efflux of antimicrobial agents in wild-type strains of enterococci. Antimicrob. Agents Chemother. 41: 869-871.

  • Charpentier, E., and P. Courvalin. 1997. Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293. Antimicrob. Agents Chemother. 41: 1134- 1136.

  • Périchon, B., J. Tankovic, and P. Courvalin. 1997. Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 41: 1166-1167.

  • Périchon B., P. Reynolds, and P. Courvalin. 1997. VanD-type glycopeptide resistant

  • Enterococcus faecium BM4339. Antimicrob. Agents Chemother. 41: 2016-2018.

  • François, B., M. Charles, and P. Courvalin. 1997. Conjugative transfer of tet(S) between strains of Enterococcus faecalis is associated with the exchange of large fragments of chromosomal DNA. Microbiology 143: 2145-2154.

  • Galimand, M., A. Guiyoule, G. Gerbaud, B. Rasoamanana, S. Chanteau, E. Carniel, and

  • P. Courvalin. 1997. Multidrug resistance in Yersinia pestis mediated by a transferable plasmid. N. Engl. J. Med. 337: 677-680.

  • Garnier, F., G. Gerbaud, P. Courvalin, and M. Galimand. 1997. Identification of clinically relevant viridans group streptococci to the species level by PCR. J. Clin. Microbiol. 35: 2337-2341.

  • Baptista, M., F. Depardieu, P. Reynolds, P. Courvalin, and M. Arthur. 1997. Mutations leading to increased levels of resistance to glycopeptide antibiotics in VanB-type enterococci. Mol. Microbiol. 25: 93-105.

  • Rudant, E., P. Courvalin, and T. Lambert. 1997. Loss of intrinsic aminoglycoside resistance in Acinetobacter haemolyticus as a result of three distinct types of alterations in the aac(6’)-Ig gene, including insertion of IS17. Antimicrob. Agents Chemother. 41: 2646-2651.

  • Guibourdenche, M., T. Lambert, P. Courvalin, and J.Y. Riou. 1997. Epidemiological survey of Neisseria meningitidis susceptibility to penicillin G in France. Path. Biol. 45: 729-736.

  • Brown, D.F.J., P. Courvalin, and the European Glycopeptide Resistance Group. 1998. Quality assessment of glycopeptide susceptibility tests: A European collaborative study. Int. J. Antimicrob. Agents 9: 153-163.

  • Aubry-Damon, H., C.-J. Soussy, and P. Courvalin. 1998. Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 42: 2590-2594.

  • Grillot-Courvalin, C., S. Goussard, F. Huetz, D.M. Ojcius, and P. Courvalin. 1998. Functional gene transfer from intracellular bacteria to mammalian cells. Nature Biotechnol. 16: 862-866.

  • Rudant, E., P. Courvalin, and T. Lambert. 1998. Characterization of IS18, an element capable of activating the silent aac(6’)-Ij gene of Acinetobacter sp. 13 strain BM2716 by transposition. Antimicrob. Agents Chemother. 42: 2759-2761.

  • Ploy, M.-C., P. Courvalin, and T. Lambert. 1998. Characterization of In40 of Enterobacter aerogenes BM2688, a class I integron with two new gene cassettes cmlB and qacF. Antimicrob. Agents Chemother. 42: 2557-2563.

  • Arthur, M., F. Depardieu, L. Cabanié, P. Reynolds, and P. Courvalin. 1998. Requirement of the VanY and VanX, D,D-peptidases for glycopeptide resistance in enterococci. Mol. Microbiol. 30: 819-830.

  • Galimand, M., G. Gerbaud, M. Guibourdenche, J.-Y. Riou, and P. Courvalin. 1998. High-level chloramphenicol resistance in Neisseria meningitidis. N. Engl. J. Med. 339: 868-874.

  • Van Bambeke, F., M. Chauvel, P.E. Reynolds, H.S. Fraimow, and P. Courvalin. 1999. Vancomycin-dependent Enterococcus faecalis clinical isolates and revertant mutants. Antimicrob. Agents Chemother. 43: 41-47.

  • Goussard, S., and P. Courvalin. 1999. Updated sequence information for TEM ß- lactamases genes. Antimicrob. Agents Chemother. 43: 367-370.

  • Arlet, G., S. Goussard, P. Courvalin, and A. Philippon. 1999. Sequence of the genes for TEM-20, TEM-21, TEM-22, and TEM-29 extended spectrum -lactamase. Antimicrob. Agents Chemother. 43: 969-971.

  • Arias, C.A., M. Martinez, T.L. Blundell, M. Arthur, P. Courvalin, and P.E. Reynolds. 1999. Characterization and modelling of VanT, a novel, membrane-bound, serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174. Mol. Microbiol. 31: 1653-1664.

  • Lefort, A., M. Baptista, F. Depardieu, M. Arthur, C. Carbon, P. Courvalin, and B. Fantin. 1999. Two-step acquisition of resistance to the teicoplanin-gentamicin combination by VanB-type Enterococcus faecalis in vitro and in experimental endocarditis. Antimicrob. Agents Chemother. 43: 476-482.

  • Baptista, M., P. Rodrigues, F. Depardieu, P. Courvalin, and M. Arthur. 1999. Single-cell analysis of glycopeptide resistance gene expression in teicoplanin-resistant mutants of a VanB-type Enterococcus faecalis. Mol. Microbiol. 31: 17-28.

  • Rudant, E., P. Bouvet, P. Courvalin, and T. Lambert. 1999. Phylogenetic analysis of proteolytic Acinetobacter strains based on the sequences of genes encoding aminoglycoside 6’-N-acetyltransferases. Syst. Appl. Microbiol. 22: 59-67.

  • Soussy, C.-J., M. Cluzel, M.-C. Ploy, M.-D. Kitzis, C. Morel, A. Bryskier, and P. Courvalin. 1999. In-vitro antibacterial activity of levofloxacin, against hospital isolates: a multicentre study. J. Antimicrob. Chemother. 43: suppl. C. : 43-50.

  • Arthur, M., F. Depardieu, P. Reynolds, and P. Courvalin. 1999. Moderate-level resistance to glycopeptide LY333328 mediated by genes from the vanA and vanB clusters in enterococci. Antimicrob. Agents Chemother. 43: 1875-1880

  • Casadewall, B., and P. Courvalin. 1999. Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339. J. Bacteriol. 181: 3644- 3648.

  • Charpentier, E., G. Gerbaud, and P. Courvalin. 1999. Conjugative mobilization of the rolling-circle plasmid pIP823 from Listeria monocytogenes BM4293 among Gram-positive and Gram-negative bacteria. J. Bacteriol. 181: 3368-3374.

  • Fines, M., B. Perichon, P. Reynolds, D. Sahm, and P. Courvalin. 1999. VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405. Antimicrob. Agents Chemother. 43: 2161-2164.

  • Arthur, M., F. Depardieu, and P. Courvalin. 1999. Regulated interactions between partner and non-partner sensors and response regulators that control glycopeptide resistance gene expression in enterococci. Microbiology 145:1849-1858.

  • Lambert, T., M.C. Ploy, F. Denis, and P. Courvalin. 1999. Characterization of the chromosomal aac(6’)-Iz gene of Stenotrophomonas maltophilia. Antimicrob. Agents Chemother. 43: 2366-2371.

  • Reynolds, P.E., C.A. Arias, and P. Courvalin. 1999. Gene vanXYC encodes D,D- dipeptidase (VanX) and D,D-carboxypeptidase (VanY) activities in vancomycin-resistant Enterococcus gallinarum BM4174. Mol. Microbiol. 36: 341-349.

  • Magnet, S., P. Courvalin, and T. Lambert. 1999. Activation of the cryptic aac(6’)-Iy aminoglycoside resistance gene of Salmonella by a chromosomal deletion generating a transcriptional fusion. J. Bacteriol. 181: 6650-6655.

  • Galimand, M., T. Lambert, G. Gerbaud, and P. Courvalin. 1999. High-level gentamicin resistance in -hemolytic group G Streptococcus BM2721. Antimicrob. Agents Chemother. 43: 3008-3010.

PUBLICATIONS: About Me

2000 - 2010

  • ​Galimand, M., G. Gerbaud, and P. Courvalin. 2000. Spectinomycin resistance in Neisseria spp. due to mutations in 16S ribosomal RNA. Antimicrob. Agents Chemother. 44: 1365-1366.

  • Périchon, B., B. Casadewall, P. Reynolds, and P. Courvalin. 2000. Glycopeptide-resistant Enterococcus faecium BM4416 is a VanD-type strain with an impaired D- alanine: D-alanine ligase. Antimicrob. Agents Chemother. 44: 1346-1348.

  • Prévost, M., D. Van Belle, P. M. Tulkens, P. Courvalin, and F. Van Bambeke. 2000. Modeling of the Enterococcus faecalis D-alanine: D-alanine ligase: Structure-based study of the active site in the wild-type enzyme and in glycopeptide-dependent mutants. J. Mol. Microbiol. Biotechnol. 2: 321-330.

  • Arias, C., P. Courvalin, and P. Reynolds. 2000. The vanC gene cluster of vancomycin-resistant Enterococcus gallinarum BM4174. Antimicrob. Agents Chemother. 44: 1660- 1666.

  • Ozawa, Y., P. Courvalin, and M. Galimand. 2000. Identification of enterococci at the species level by sequencing of the genes for the D-alanine: D-alanine ligase. Syst. Appl. Microbiol. 23: 230-237.

  • Ploy, M.-C., F. Denis, P. Courvalin, and T. Lambert. 2000. Molecular characterization of integrons in Acinetobacter baumannii: Description of a hybrid class 2 integron. Antimicrob. Agents Chemother. 44: 2684-2688.

  • Lefort, A., M. Arthur, L. Garry, C. Carbon, P. Courvalin, and B. Fantin. 2000. Bactericidal activity of gentamicin against Enterococcus faecalis in vitro and in vivo. Antimicrob. Agents Chemother. 44: 2077-2080.

  • Garnier, F., S. Taourit, P. Glaser, P. Courvalin, and M. Galimand. 2000. Characterization of transposon Tn1549 conferring VanB-type resistance in Enterococcus spp. Microbiology 146: 1481-1489.

  • Cao, V.T.B., G. Arlet, B.-M. Ericsson, A. Tammelin, P. Courvalin, and T. Lambert. 2000. Emergence of imipenen resistance in Klebsiella pneumoniae due to combination of plasmid-mediated CMY-4 production and permeability alteration. J. Antimicrob. Chemother. 46: 895-900.

  • Tait-Kamradt, A., T. Davies, P.C. Appelbaum, F. Depardieu, P. Courvalin, J. Petitpas, L. Wondrack, A. Walker, M. Jacobs, and J. Sutcliffe. 2000. Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America. Antimicrob. Agents Chemother. 44: 3395-3401.

  • Auckenthaler, R., P. Courvalin, C. Féger, G. Roche, and an international study working group. 2000. In vitro activity of quinupristin/dalfopristin in comparison with five antibiotics against worldwide clinical isolates of staphylococci. Clin. Microbiol. Infect. 6: 608-612.

  • Araoz, R., E. Anhalt, L. René, M.A. Badet-Denisot, P. Courvalin, and B. Badet. 2000. Mechanism-based inactivation of VanX, a D-alanyl-D-alanine dipeptidase necessary for vancomycin resistance. Biochemistry 30: 1571-1579.

  • Guiyoule, A., G. Gerbaud, C. Buchrieser, M. Galimand, L. Rahalison, S. Chanteau, P. Courvalin, and E. Carniel. 2001. Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis. Emerg. Infect. Dis. 7: 43-48.

  • Depardieu, F., and P. Courvalin. 2001. Mutation in 23S rRNA responsible for  resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 45: 319-323.

  • Gholizadeh, Y., M. Prévost, F. Van Bambeke, B. Casadewall, and P. Courvalin. 2001. Sequencing of the ddl gene and modeling of the mutated D-alanine: D-alanine ligase in glycopeptide-dependent strains of Enterococcus faecium. Protein Science 10:836-844.

  • Casadewall, B., P.E. Reynolds, and P. Courvalin. 2001. Regulation of expression of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339. J. Bacteriol. 183: 3436-3446.

  • Reynolds, P.E., O.H. Ambur, B. Casadewall, and P. Courvalin. 2001. The VanYD D,D- carboxypeptidase of Enterococcus faecium BM4339 is a penicillin binding protein. Microbiology 147: 2571-2578.

  • Magnet, S., T. Lambert, P. Courvalin, and J. Blanchard. 2001. Kinetic and mutagenic characterization of the chromosomally-encoded Salmonella enterica AAC(6’)-Iy aminoglycoside N-acetyltransferase. Biochemistry 40: 3700-3709.

  • Magnet, S., P. Courvalin, and T. Lambert. 2001. Resistance-nodulation-cell division type efflux pump involved in aminoglycoside resistance in Acinetobacter baumanii strain BM4454. Antimicrob. Agents Chemother. 45: 3375-3380.

  • Lafaurie, M., B. Périchon, A. Lefort, C. Carbon, P. Courvalin, and B. Fantin. 2001. Consequences of VanE-type resistance on efficacy of glycopeptides in vitro and in experimental endocarditis due to Enterococcus faecalis. Antimicrob. Agents Chemother. 45: 2826-2830.

  • Grillot-Courvalin, C., S. Goussard, and P. Courvalin. 2002. Wild-type intracellular bacteria deliver DNA into mammalian cells. Cell. Microbiol. 4:177-186.

  • Umeda, A., F. Garnier, P. Courvalin, and M. Galimand. 2002. Association between the vanB2 glycopeptide resistance operon and Tn1549 in enterococci from France. J. Antimicrob. Chemother. 50: 253-256.

  • Decousser, J.W., P.Y. Allouch, P. Courvalin, R. Leclercq, and the Study Group. 2002. In vitro activity of moxifloxacin against recent community-acquired respiratory tract pathogens isolated in France: A national survey. Int. J. Antimicrob. Agents 20 : 186- 195.

  • Cao, V.T.B., T. Lambert, and P. Courvalin. 2002. ColE1-like plasmid pIP843 from Klebsiella pneumoniae encoding extended-spectrum ß-lactamase CTX-M-17. Antimicrob. Agents Chemother. 46: 1212-1217.

  • Aubry-Damon, H., M. Galimand, G. Gerbaud, and P. Courvalin. 2002. rpoB mutation conferring rifampin resistance in Streptococcus pyogenes. Antimicrob. Agents Chemother. 46:1571-1573.

  • Alonso, R., G. Gerbaud, M. Galimand, and P. Courvalin. 2002. TEM-103/IRT-28 ß- lactamase, a new TEM variant produced by Escherichia coli BM4511. Antimicrob. Agents Chemother. 46:3627-3629.

  • Alonso, R., M. Galimand, and P. Courvalin. 2002. parC mutation conferring ciprofloxacin resistance in Streptococcus pyogenes BM4513. Antimicrob. Agents Chemother. 46:3686-3687.

  • Cao, V.T.B., T. Lambert, D.Q. Nhu, H.K. Loan, N.K. Hoang, G. Arlet, and P. Courvalin. 2002. Distribution of extended-spectrum ß-lactamases in clinical isolates of Enterobacteriaceae in Vietnam. Antimicrob. Agents Chemother. 46: 3739-3743.

  • Abadia Patiño, L., P. Courvalin, and B. Périchon. 2002. vanE gene cluster of vancomycin resistant Enterococcus faecalis BM4405. J. Bacteriol. 184: 6457-6464.

  • Bronzwaer, S., U. Buchholz, P. Courvalin, J. Snell, G. Cornaglia, A. de Neeling, H. Aubry-Damon, J. Degener, and EARSS participants. 2002. Comparability of antimicrobial susceptibility test results from 22 European countries and Israel: an external quality assurance exercise of the European Antimicrobial Resistance Surveillance System (EARSS) in collaboration with the United Kingdom National External Quality Assurance Scheme (UK NEQAS). J. Antimicrobial. Chemother. 50: 953-964.

  • Depardieu, F., P.E. Reynolds, and P. Courvalin. 2003. VanD-type vancomycin-resistant Enterococcus faecium 10/96A. Antimicrob. Agents Chemother. 47: 7-18.

  • Godreuil, S., M. Galimand, G. Gerbaud, C. Jacquet, and P. Courvalin. 2003. Efflux pump Lde is associated with fluoroquinolone resistance in Listeria monocytogenes CLIP 21369. Antimicrob. Agents Chemother. 47: 704-708.

  • Bozdogan, B., S. Galopin, G. Gerbaud, P. Courvalin, and R. Leclercq. 2003. Chromosomal aadD2 gene encodes an aminoglycoside nucleotidyltransferase in Bacillus clausii. Antimicrob. Agents Chemother. 47 : 1343-1346.

  • Sabtcheva, S., T. Lambert, G. Gerbaud, M. Galimand, and P. Courvalin. 2003. Aminoglycoside resistance gene ant(4’)-IIb of Pseudomonas aeruginosa BM4492, a clinical isolate from Bulgaria. Antimicrob. Agents Chemother. 47: 1584-1588.

  • Temine, L., P.-Y. Boëlle, P. Courvalin, and D. Guillemot. 2003. Mathematical modeling of the emergence and spread of bacterial resistance to penicillin G by decreased affinity of penicillin binding proteins. Emerg. Infect. Dis. 9 : 411-417.

  • Decousser, J.W., P. Pina, C. Delalande, B. Pangon, P. Courvalin, P. Allouch, and the ColBVH study group. 2003. Frequency of isolation and antimicrobial susceptibility of bacterial pathogens isolated from patients with bloodstream infections: a French prospective national survey. J. Antimicrob. Chemother. 51: 1213-1222.

  • Galimand, M., P. Courvalin, and T. Lambert. 2003. Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation. Antimicrob. Agents Chemother. 47: 2565-2571.

  • Moubareck, C., N. Bourgeois, P. Courvalin, and F. Doucet-Populaire. 2003. Multiple antibiotic resistance gene transfer from animal to human enterococci in the digestive tract of gnotobiotic mice. Antimicrob. Agents Chemother. 47: 2993-2996.

  • Kehoe, L.E., J. Snidwongse, P. Courvalin, J.B. Rafferty, and I.A. Murray. 2003. Structural basis of Synercid® (quinupristin-dalfopristin) resistance in gram-positive bacterial pathogens. J. Biol. Chem. 278: 29963-29970.

  • Goossens, H., D. Jabes, R. Rossi, C. Lammens, G. Privitera, and P. Courvalin. 2003. European survey of vancomycin-resistant enterococci in at-risk hospital wards and in vitro susceptibility testing of ramoplanin against these isolates. J. Antimicrob. Chemother. 51 suppl. S3: 5-12.

  • Depardieu F., P. Courvalin, and T. Msadek. 2003. A six amino acid deletion, partially overlapping the VanSB G2 ATP-binding motif, leads to constitutive glycopeptide resistance in VanB-type Enterococcus faecium. Mol. Microbiol. 50: 1069-1083.

  • Depardieu, F., M.-G. Bonora, P.E. Reynolds, and P. Courvalin. 2003. The vanG glycopeptide resistance operon from Enterococcus faecalis revisited. Mol. Microbiol. 50: 931-948.

  • Soussy, C.-J., J. Nguyen, F. Goldstein, H. Dabernat, A. Andremont, R. Leclercq, H. Drugeon, P. Cavallo, H. Chardon, J. Etienne, Y. Rio, and P. Courvalin. 2003. In vitro antibacterial activity of moxifloxacin against hospital isolates: a multicentre study. Clin. Microbiol. Infect. 9: 997-1005.

  • Lefort, A., L. Garry, F. Depardieu, P. Courvalin, and B. Fantin. 2003. Influence of VanD-type resistance on activities of glycopeptides in vitro and in experimental endocarditis due to Enterococcus faecium. Antimicrob. Agents Chemother. 47: 3515- 3518.

  • Goussard, S., C. Grillot-Courvalin, and P. Courvalin. 2003. Eukaryotic promoters can direct protein synthesis in Gram-negative bacteria. J. Mol. Microbiol. Biotechnol 6: 211-218.

  • Lefort, A., M. Arthur, F. Depardieu, N. Pham, F. Chau, C. Pouzet, P. Courvalin, and B. Fantin. 2004. Expression of glycopeptide-resistance gene in response to vancomycin and teicoplanin in the cardiac vegetations of rabbits infected with VanB-type Enterococcus faecalis. J. Infect. Dis. 189: 90-97.

  • Decousser, J.-W., P. Pina, F. Viguier, F. Picot, P. Courvalin, P. Allouch, and the ColBVH study group. 2004. Invasive Streptococcus pneumoniae in France: Antimicrobial resistance, serotype, and molecular epidemiology findings from a monthly national study in 2000 to 2002. Antimicrob. Agents Chemother. 48: 3636- 3639.

  • Marchand, I., L. Damier-Piolle, P. Courvalin, and T. Lambert. 2004. Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system. Antimicrob. Agents Chemother. 48: 3298-3304.

  • Depardieu, F., M. Kolbert, H. Pruul, J. Bell, and P. Courvalin. 2004. Characterization of new VanD-type vancomycin-resistant Enterococcus faecium and Enterococcus faecalis. Antimicrob. Agents Chemother. 48:3892-3904.

  • Depardieu, F., B. Périchon, and P. Courvalin. 2004. Detection of the van alphabet and identification of enterococci and staphylococci at the species level by multiplex PCR. J. Clin. Microbiol. 42 : 5857-5860.

  • Périchon, B., and P. Courvalin. 2004. Heterologous expression of the enterococcal vanA operon in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 48 : 4281-4285.

  • Abadia-Patiño, L., K. Christiansen, J. Bell, P. Courvalin, and B. Périchon. 2004. VanE- type vancomycin-resistant Enterococcus faecalis clinical isolates from Australia. Antimicrob. Agents Chemother. 48 : 4882-4885.

  • Gonzalez-Zorn, B., J.P.M. Senna, L. Fiette, S. Shorte, A. Testard, M. Chignard, P. Courvalin, and C. Grillot-Courvalin. 2005. Bacterial and host factors implicated in nasal carriage of methicillin-resistant Staphylococcus aureus in mice. Infect. Immun. 73: 1847-1851.

  • Gonzalez-Zorn, B., T. Teshager, M. Casas, M.C. Porrero, M.A. Moreno, P. Courvalin, and L. Dominguez. 2005. armA and aminoglycoside resistance in Escherichia coli. Emerg. Infect. Dis. 11: 954-956.

  • Panesso, D., L. Abadia-Patiño, N. Vanegas, P. Reynolds, P. Courvalin, and C. A. Arias. 2005. Transcriptional analysis of the vanC cluster from constitutive and inducible strains of vancomycin-resistant Enterococcus gallinarum Antimicrob. Agents Chemother. 49 : 1060-1066.

  • Abadia-Patiño, L., M. Chippaux, P. Courvalin, and B. Périchon. 2005. Silencing of glycopeptide resistance in Enterocccus faecalis BM4405 by novobiocin. Antimicrob. Agents Chemother. 49: 1419-1425.

  • Skurnik, D., A. Le Menac’h, D. Zurakowski, D. Mazel, P. Courvalin, E. Denamur, A. Andremont, and R. Ruimy. 2005. Integron-associated antibiotic resistance and phylogenetic grouping of Escherichia coli from healthy subjects free of recent antibiotic exposure. Antimicrob. Agents Chemother. 49: 3062-3065.

  • Galimand, M., S. Sabtcheva, P. Courvalin, and T. Lambert. 2005. Wordwide disseminated armA aminoglycoside resistance methylase gene is borne by composite transposon Tn1548. Antimicrob. Agents Chemother. 49: 2949-2953.

  • Depardieu, F., P. Courvalin, and A. Kolb. 2005. Binding sites of VanRB and ⌠RNA polymerase in the vanB vancomycin resistance operon of Enterococcus faecium BM4524. Mol. Microbiol. 57: 550-564.

  • Alonso, R., E. Mateo, M. Galimand, J. Garaizar, P. Courvalin, and R. Cisterna. 2005. Clonal spread of pediatric iolates of ciprofoxacin-resistant, emm type 6 Streptococcus pyogenes. J. Clin. Microbiol. 43: 2492-2493.

  • Laner, A., S. Goussard, A.S. Ramalho, M.D. Amaral, P. Courvalin, D. Schindelhauer, and C. Grillot-Courvalin. 2005. Bacterial transfer of functional genomic DNA in human cells. Gene Ther. 12: 1559-1572.

  • Girard-Blanc, C., and P. Courvalin. 2005. Evaluation of non-automated techniques for phenotypic detection of VanA-type Staphylococcus aureus Eur. J. Clin. Microbiol. Infect. Dis. 24: 562-565.

  • Guardabassi, L., B. Périchon, J. Van Heijenoort, D. Blanot, and P. Courvalin. 2005. Glycopeptide-resistance vanA operons in Paenibacillus strains from soil. Antimicrob. Agents Chemother. 49: 4227-4233.

  • Liou, F.G., S. Yoshizawa, P. Courvalin, and M. Galimand. 2006. Aminoglycoside resistance by ArmA-mediated ribosomal 16S methylation in human bacterial pathogens. J. Mol. Biol. 359: 358-364.

  • Aslangul, E., L. Massias, A. Meulemans, F. Chau, A. Andremont, P. Courvalin, B. Fantin, and R. Ruimy. 2006. Acquired gentamicin resistance by permeability impairment in Enterococcus faecalis. Antimicrob. Agents Chemother. 50: 3615-3621.

  • Périchon B. and P. Courvalin. 2006. Synergism between ß-lactams and glycopeptides against VanA-type methicillin-resistant Staphylococcus aureus and heterologous expression of the vanA operon. Antimicrob. Agents Chemother. 50: 3622-3630.

  • Chesneau, O., K. Tsvetkova, and P. Courvalin. 2007. Resistance phenotypes conferred by macrolide phosphotransferases. FEMS Microbiol. Lett. 269:317-322.

  • Tristan, A., M. Bes, H. Meugnier, G. Lina, B. Bozdogan, P. Courvalin, M.-E. Reverdy, M.C. Enright, F. Vandenesch, and J. Etienne. 2007. Global distribution of Panton Valentine Leucocidin-positive methicillin-resistant Staphylococcus aureus, 2006. Emerg. Infect. Dis. 13:594-600.

  • Périchon, B., P. Courvalin, and M. Galimand. 2007. Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. Antimicrob. Agents Chemother. 51: 2464-2469.

  • Damier-Piolle, L., S. Magnet, S. Brémont, T. Lambert and P. Courvalin. 2008. AdeIJK, a RND pump effluxing multiple antibiotics in Acinetobacter baumannii. Antimicrob. Agents Chemother. 52: 557-562.

  • Meziane-Cherif, D., D. Decré, A.E. Høiby, P. Courvalin, and B. Périchon. 2008. Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. Antimicrob. Agents Chemother. 52: 551-556.

  • Larsen, M.D.B., U. Griesenbach, S. Goussard, D.C. Gruenert, D.M. Geddes, R.K. Scheule, S.H. Cheng, P. Courvalin, C. Grillot-Courvalin, and E.W.F.W. Alton. 2008. Bactofection of lung epithelial cells in vitro and in vivo using a genetically modified Escherichia coli. Gene Ther. 15 : 434-442.

  • Meziane-Cherif, D., T. Lambert, M. Dupechez, P. Courvalin, and M. Galimand. 2008. Genetic and biochemical characterization of OXA-63, a new class D ß-lactamase from Brachyspira pilosicoli BM4442. Antimicrob. Agents Chemother. 52 : 1264-1268.

  • Périchon, B., P. Bogaerts, T. Lambert, P. Courvalin, and M. Galimand. 2008. Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosides by rRNA methylation and to hydrophilic fluoroquinolones by efflux. Antimicrob. Agents Chemother. 52 : 2581-2592.

  • Lismond, A., P.M. Tulkens, M.-P. Mingeot-Leclercq, P. Courvalin, and F. Van Bambeke. 2008. Cooperation between prokaryotic (Lde) and eukaryotic (MRP) efflux transporters in J774 macrophages infected with Listeria monocytogenes. Studies with ciprofloxacin and moxifloxacin. Antimicrob. Agents Chemother. 52: 3040-3046.

  • Page, S., F. Vernel-Pauillac, F. Charavay, C. Goarant, P. Courvalin, and S. Le Hello. 2008. RT-PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 52: 4155-4158.

  • Depardieu, F., M.-L. Foucault, J. Bell, A. Dubouix, M. Guibert, J.-P. Lavigne, M. Levast, and P. Courvalin. 2009. New combinations of mutations in VanD-type vancomycin resistant Enterococcus faecium, Enterococcus faecalis, and Enterococcus avium strains. Antimicrob. Agents Chemother. 53: 1952-1963.

  • San Millan, A., F. Depardieu, S. Godreuil, and P. Courvalin. 2009. VanB-type Enterococcus faecium clinical isolate successively inducibly resistant to, dependent on, and constitutively resistant to vancomycin. Antimicrob. Agents Chemother. 53: 1974- 1982.

  • Foucault, M.-L., P. Courvalin, and C. Grillot-Courvalin. 2009. Fitness cost of VanA- type vancomycin resistance in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 53: 2354-2359.

  • Schmitt, E., M. Galimand, M. Panvert, P. Courvalin, and Y. Mechulam. 2009. Structural bases for 16S rRNA methylation catalyzed by ArmA and RmtB methyltransferases. J. Mol. Biol. 388: 570-582.

  • Moubareck, C., S. Brémont, M.-C. Conroy, P. Courvalin, and T. Lambert. 2009. GES- 11, a novel integron-associated GES variant, in Acinetobacter baumannii. Antimicrob. Agents Chemother. 53:3579-3581.

  • Moubareck, C., D. Meziane-Cherif, P. Courvalin, and B. Périchon. 2009. VanA-type Staphylococcus aureus VRSA-7 is partially dependent on vancomycin for growth. Antimicrob. Agents Chemother. 53: 3657-3663.

  • Skurnik, D., S. Lasocki, S. Brémont, C. Muller-Serieys, M.-D. Kitzis, P. Courvalin, A. Andremont, and P. Montravers. 2009. Development of ertapenem resistance in a patient with mediastinitis caused by an extended-spectrum beta-lactamase producing Klebsiella pneumoniae. J. Med. Microbiol. 59: 115-119.

  • Daurel, C., A.-L. Fiant, S. Brémont, P. Courvalin, and R. Leclercq. 2009. Emergence of an Enterobacter hormaechei strain with reduced susceptibility to tigecycline under tigecycline therapy. Antimicrob. Agents Chemother. 53: 4953-49546.

  • Weber, P., D. Meziane-Cherif, A. Haouz, F. A. Saul, and P. Courvalin. 2009. Crystallization and preliminary X-ray analysis of D-Ala: D-Ser ligase associated with VanG-type vancomycin resistance in Enterococcus faecalis BM4518. Acta Crystollogr. Sect. F Struct. Biol. Cryst. Commun. Section F65:1024-1026.

PUBLICATIONS: About Me

2010 - 2020

  • Coyne, S., G. Guigon, P. Courvalin, and B. Périchon. 2010. Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. Antimicrob. Agents Chemother. 54:333-340.

  • Ruimy, R., A. Brisabois, C. Bernède, D. Skurnik, S. Barnat, F. Moury, A.-M. Vibert, P. Courvalin, D. Guillemot, and A. Andremont. 2010. Organic and conventional fruits and vegetables contain equivalent counts of environmental bacteria expressing resistance to antibacterial agents. Environ. Microbiol. 12(3): 608-615.

  • Skurnik, D., A. Nucci, R. Ruimy, A. Andremont, P. Courvalin. 2010. Emergence of carbapenem-resistant Hafnia. The fall of the last « soldier ». Clin. Infect. Dis. 10: 1429- 1431.

  • Coyne, S., P. Courvalin, M. Galimand. 2010. Acquisition of multidrug resistance transposon Tn6061 and IS6100-mediated large chromosomal inversions in Pseudomonas aeruginosa clinical isolates. Microbiology 156: 1448-1458.

  • Ruimy, R., D. Meziane-Cherif, S. Momcilovic, G. Arlet, A. Andremont, and P. Courvalin. 2010. RAHN-2, a chromosomal extended-spectrum class A-lactamase from Rahnella aquatilis. J. Antimicrob. Chemother. 65: 1619-1623.

  • Morvan, A., C. Moubareck, A. Leclercq, M. Hervé-Bazin, S. Brémont, M. Lecuit, P. Courvalin, and A. Le Monnier. 2010. Antimicrobial resistance of Listeria monocytogenes strains isolated from humans in France. Antimicrob. Agents Chemother. 54: 2728-2731.

  • Foucault, M. L., L. Thomas, S. Goussard, B. R. Branchini, and C. Grillot-Courvalin. 2010. In vivo bioluminescence imaging for the study of intestinal colonization by Escherichia coli in mouse. Appl. Environ. Microbiol. 76: 264-274.

  • Coyne, S., N. Rosenfeld, T. Lambert, P. Courvalin, and B. Périchon. 2010. Overexpression of Resistance-Nodulation-Cell Division Pump AdeFGH confers Multidrug Resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 54: 4389-4393.

  • Foucault, M.-L., F. Depardieu, P. Courvalin, and C. Grillot-Courvalin. 2010. Inducible expression eliminates the fitness cost of vancomycin resistance in enterococci. Proc. Natl. Acad. Sci. U.S.A. 107: 16964-16969

  • Meziane-Cherif, D., F. A. Saul, C. Moubareck, P. Weber, A. Haouz, P. Courvalin, and B. Périchon. 2010. Molecular basis of vancomycin-dependence in VanA-type Staphylococcus aureus VRSA-9. J. Bacteriol. 192: 5465-5471.

  • El Garch, F., A. Lismond, L. J. V. Piddock, P. Courvalin, P. M. Tulkens, and F. Van Bambeke. 2010. Fluoroquinolones induce the expression of PatA and PatB efflux pumps in Streptococcus pneumoniae. J. Antimicrob. Chemother. (65)10:2076-2082.

  • Galimand, M., E. Schmitt, M. Panvert, S. Douthwaite, Y. Mechulam, and P. Courvalin. 2011. Intrinsic resistance to aminoglycosides in Enterococcus faecium is conferred by the 16S rRNA m5C1404-specific methyltransferase EfmM. RNA 17:251-262.

  • Granier, S.A., C. Moubareck, C. Colaneri, A. Lemire, S. Roussel, T.-T. Dao, P. Courvalin, and A. Brisabois. 2011. Antimicrobial resistance of Listeria monocytogenes isolated from food and environment in France over a 10 year period. Appl. Environ. Microbiol. 77:2788-2790.

  • Hocquet, D., M. Colomb, B. Dehecq, O. Belmonte, P. Courvalin, P. Plésiat, and D. Meziane-Cherif. 2011. Ceftazidime-hydrolysing-lactamase OXA-145 with impaired hydrolysis of penicillins in Pseudomonas aeruginosa. J. Antimicrob. Chemother. 66:1745-1750.

  • Lebreton, F., F. Depardieu, N. Bourdon, M. Fines-Guyon, P. Berger, S. Camiade, R. Leclercq, P. Courvalin, and V. Cattoir. 2011. D-Ala-D-Ser VanN-type of transferable vancomycin resistance in Enterococcus faecium. Antimicrob. Agents Chemother. 55:4606-4612.

  • Rosenfeld, N., C. Bouchier, P. Courvalin, and B. Périchon. 2012. Expression of the Resistance-Nodulation-Cell Division pump AdeLJK in Acinetobacter baumannii is regulated by AdeN, a TetR-type regulator. Antimicrob. Agents Chemother. 56:2504-2510.

  • Périchon, B. and P. Courvalin. 2012. Staphylococcus aureus VRSA-11B is a constitutive vancomycin-resistant mutant of vancomycin-dependent VRSA-11A. Antimicrob. Agents Chemother. 56:4693-4696.

  • Galimand, M., P. Courvalin, and T. Lambert. 2012. RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family. Antimicrob. Agents Chemother. 56:3960-3962.

  • Meziane-Cherif, D., F. A. Saul, A. Haouz, and P. Courvalin. 2012. Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis. J. Biol. Chem. 287:37583-37592.

  • Yoon, E.-J., P. Courvalin, and C. Grillot-Courvalin. 2013. RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: Major role for AdeABC overexpression and AdeRS mutations. Antimicrob. Agents Chemother. 57:2989-2995.

  • Amman, F., D. Meziane-Cherif, D. Mengin-Lecreulx, D. Blanot, D. Patin, I. G. Boneca,

  • P. Courvalin, T. Lambert, and T. Candela. 2013. The functional vanGCd cluster of Clostridium difficile does not confer vancomycin resistance. Mol. Microbiol. 89(4):612- 625.

  • Lesho, E., E.-J. Yoon, P. McGann, E. Snesrud, Y. Kwak, M. Milillo, F. Onmus-Leone, L. Preston, K. St. Clair, M. Nikolich, H. Viscount, G. Wortmann, M. Zapor, C. Grillot- Courvalin, P. Courvalin, R. Clifford, and P.E. Waterman. 2013. Colistin-resistant Acinetobacter baumannii containing a novel pmrCAB operon emerge during therapy. J. Infect. Dis. 208:1142-1151.

  • Périchon B., S. Goussard, V. Walewski, L. Krizoka, G. Cerqueira, C. Murphy, M. Feldgarden, J. Wortman, D. Clermont, A. Nemec, and P. Courvalin. 2013. Identification of fifty-one class D-lactamases and of fifty-four Acinetobacter-Derived Cephalosporinases in Acinetobacter spp. Antimicrob. Agents Chemother. 58:936-949.

  • Lioy, V.S., S. Goussard, V. Guerineau, E.-J. Yoon, P. Courvalin, M. Galimand, and C. Grillot-Courvalin. 2014. Aminoglycoside resistance 16S rRNA methyltransferases block endogenous methylation, affect translation efficiency and fitness of the host. RNA 20:382-391.

  • Bouvier, G., N. Duclert-Savatier, N. Desdouits, D. Meziane-Cherif, A. Blondel, P. Courvalin, M. Nilges, and T. E. Malliavin. 2014. Functional motions modulating VanA ligand binding unraveled with self-organizing maps. J. Chem. Inf. Model. 54:289-301.

  • McGann, P., P. Courvalin, E. Snesrud, R. J. Clifford, E.-J. Yoon, F. Onmus-Leone, A. C. Ong, Y. I. Kwak, C. Grillot-Courvalin, E. Lesho, and P. E. Waterman. 2014. Amplification of aminoglycoside resistance gene apha1 in Acinetobacter baumannii results in tobramycin therapy failure. mBio 5:e00915-14.

  • Jeannot, K., L. Diancourt, S. Vaux, M. Thouverez, A. Ribeiro, B. Coignard, P. Courvalin, and S. Brisse. 2014. Molecular epidemiology of carbanem non-susceptible Acinetobacter baumannii in France. PLoS ONE 9:e115452.

  • Meziane-Cherif, D., P. J. Stogios, E. Evdokimova, A. Savchenko, and P. Courvalin. 2014. Structural basis for the evolution of vancomycin resistance D, D-peptidases. Proc. Natl. Acad. Sci. USA. 111:5872-5877.

  • Chenal-Francisque, V., C. Charlier, S. Mehvish, H. Dieye, A. Leclercq, P. Courvalin, and M. Lecuit. 2014. Highly rifampicin-resistant Listeria monocytogenes isolated from a patient with prosthetic bone infection. Antimicrob. Agents Chemother. 58:1829-1830.

  • Oxford, J., E. N. Berezin, P. Courvalin, D. Dwyer, M. Exner, L. A. Jana, M. Kaku, C. Lee, K. Letlape, D. E. Low, T. A. Madani, J. R. Rubino, N. Saini, B. D. Schoub, C. Signorelli, P. M. Tierno, and X. Zhong. 2014. The survival of influenza A(H1N1)pdm09 virus on 4 household surfaces. Am. J. Infect. Control 42:423-425.

  • Guérin, F., M. Galimand, F. Tuambilangana, P. Courvalin, and V. Cattoir. 2014. FepA, a novel MATE efflux pump responsible for fluoroquinolones resistance in Listeria monocytogenes. PLos ONE 9:e106340.

  • Touchon, M., J. Cury, E.-J. Yoon, L. Krizova, G. Cerqueira, C. Murphy, M. Feldgarden,

  • J. Wortman, D. Clermont, T. Lambert, C. Grillot-Courvalin, A. Nemec, P. Courvalin, and E. Rocha. 2014. The genomic diversification of the Acinetobacter genus: origins, mechanisms and consequences. Genome Biol. Evol. 6:2866-2882.

  • Yoon, E.-J., L. Krizova, S. Goussard, M. Touchon, C. Murphy, C. Grillot-Courvalin, T. Lambert, A. Nemec, and P. Courvalin. 2014. Aminoglycoside modifying enzyme Aph(3’)-VI originates in Acinetobacter guillouiae. mBio 5:e01972-14.

  • Hombach, M., P. Courvalin, and E. Böttger. 2014. Validation of antibiotic susceptibility testing guidelines in a routine clinical microbiology laboratory exemplifies general key challenges in setting clinical breakpoints. Antimicrob. Agents Chemother. 58:3921- 3926.

  • Stogios, P.J., M. L. Kuhn, E. Evdokimova, P. Courvalin, W. Anderson, and A. Savchenko. 2014. Structure-function studies of streptogramin resistance enzyme VatA provide avenues for antibiotic improvement. Antimicrob. Agents Chemother. 12:7083-7092.

  • Maurer, F.P., P. Courvalin, E.C. Böttger, and M. Hombach, 2014. Integrating forecast probabilities in antibiograms – a way to guide antimicrobial prescriptions more reliably? J. Clin. Microbiol 52: 3674-3684.

  • Yoon, E.-J., Y. Nait Chabane, S. Goussard, E. Snesrud, P. Courvalin C., E. Dé, and C. Grillot-Courvalin. 2015. Contribution of Resistance-Nodulation-Cell division efflux systems to antibiotic resistance and biofilm formation in Acinetobacter baumannii. mBio 3:e00309-15.

  • Valsesia, G., M. Hombach, F.P. Maurer, P. Courvalin, and E. Böttger. 2015. The resistant population cut-off (RCOFF): A new concept for improved characterization of antimicrobial susceptibility patterns of non-wild-type bacterial populations. J. Clin. Microbiol. 53:1806-1811.

  • Berthet, N., B. Périchon, C. Mazuet, D. Chapetón-Montes, C. Bouchier, P. Bouvet, C. Legeay, M.-R. Popoff, and P. Courvalin. 2015. A vanG-type locus in Clostridium argentinense. J. Antimicrob. Chemother. 70:1942-1945.

  • Stogios, P.J., E. Evdokimova, M. Morar, K. Koteva, G.D. Wright, P. Courvalin, and A. Savchenko. 2015. Structural and functional plasticity of resistance nucleotidytransferases revealed by molecular characterization of lincosamide nucleotidyltransferase Lnu(A) and Lnu(D). J. Mol. Biol. 427:2229-2243.

  • Breidenstein, E., P. Courvalin, and D. Meziane-Cherif. 2015. Antimicrobial activity of plectasin NZ2114 in combination with cell wall targeting antibiotics against VanA-type Enterococcus faecalis. Microb. Drug Resist. 21:373-379.

  • Depardieu, F., V. Méjean, and P. Courvalin. 2015. Competition between VanUG repressor and VanRG activator leads to rheostatic control of vanG vancomycin resistance operon expression. PLoS Genet. 11(4):e1005170.

  • Meziane-Cherif, D., P.J. Stogios, E. Evdokimova, O. Egorova, A. Savchenko, and P. Courvalin. 2015. Molecular basis of the specificity of vancomycin resistance VanT serine racemases. mBio 6(4): e00806-15.

  • Galimand, M., J. Fishovitz, T. Lambert, V. Barbe, S. Mobashery, and P. Courvalin. 2015. AAC(3)-XI, a new aminoglycoside 3-N-acetyltransferase from Corynebacterium stritum. Antimicrob. Agents Chemother. 59(9):5647-5653.

  • Meziane-Cherif, D., R. Bonnet, A. Haouz, and P. Courvalin. 2016. Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 β- lactamase in Pseudomonas aeruginosa. J. Antimicrob. Chemother. 71(2):395-402.

  • Yoon, E.-J., S. Goussard, A. Nemec, T. Lambert, P. Courvalin, and C. Grillot-Courvalin. 2016. Origin in Acinetobacter gyllenbergii and dissemination of aminoglycoside- modifying enzyme AAC(6’)-Ih. J. Antimicrob. Chemother. 71(3):601-606.

  • Mazuet, C., E.-J. Yoon, S. Boyer, S. Pignier, T. Blanc, I. Doehring, D. Meziane-Cherif, C. Dumant-Forest, J. Sautereau, C. Legeay, P. Bouvet, C. Bouchier, S. Quijano-Roy, M. Pestel-Caron, P. Courvalin, and M.R. Popoff. 2016. A penicillin and metronidazole resistant Clostridium botulinum strain responsible for an infant botulism case. Clin. Microbiol. Infect. 22(7):644.e7-644.e12.

  • Yoon, E.-J., V. Balloy, L. Fiette, M. Chignard, P. Courvalin, and C. Grillot-Courvalin. 2016. Contribution of the Ade RND-type efflux pumps to fitness and pathogenesis in Acinetobacter baumannii. mBio 3:e00697-16.

  • Al-Agamy, M.H., K. Jeannot, T.S. El-Mahdy, H.A. Samaha, A.M. Shibl, P. Plésiat, and P. Courvalin. 2016. Diversity of molecular mechanisms conferring carbapenem resistance to Pseudomonas aeruginosa isolates in Saudi Arabia. Can. J. Infect. Dis. Med. Microbiol. Doi: 10.1155/2016/4379686. Epub 2016 Aug 11

  • Al-Agamy, M.H., K. Jeannot, T.S. El-Mahdy, A.M. Shibl, W. Kattan, P. Plésiat, and P. Courvalin. 2016. First detection of GES-5 carbapenemase-producing Acinetobacter baumannii isolate. Microb. Drug. Resist.

  • Stogios, P.J., M.L. Kuhn, E. Evdokimova, M. Law, P. Courvalin, and A. Savchenko. 2017. Structural and biochemical characterisation of Acinetobacter spp. aminoglycoside acetyltransferases highlights functional and evolutionary variation among antibiotic resistance enzymes. ACS Infect. Dis. 10:132-143.

  • Yoon, E.-J., C. Grillot-Courvalin, and P. Courvalin. 2017. Aminoglycoside-modifying enzymes APH(3’)-VIII and APH(3’)-IX in Acinetobacter rudis and Acinetobacter gerneri. J. Antibiot. (Tokyo). 70:400-403.

  • Cecchini, T., Yoon, E.-J., Charretier, Y., Bardet, C., Beaulieu, C., Lacoux, X., Docquier, J. D., Lemoine, J., Courvalin, P., Grillot-Courvalin, C., Charrier, J. P. 2018. Deciphering Multifactorial Resistance Phenotypes in Acinetobacter baumannii by Genomics and Targeted Label-free Proteomics.

  • Mol Cell Proteomics. 17(3):442-456.

  • Mancini, S., Marchesi, M,. Blöchliger, N., Schmid, M., Courvalin, P., Keller, P. M., Böttger, E. C. 2018. Combining forecast probabilities with graphical visualization for improved reporting of antimicrobial susceptibility testing. J Antimicrob Chemother. 73(8):2266-2268.

  • Mancini, S., Marchesi, M., Imkamp, F., Wagner, K., Keller, P. M., Quiblier, C., Bodendoerfer, E., Courvalin, P., Böttger, E. C. 2019. Population-based inference of aminoglycoside resistance mechanisms in Escherichia coli. EBioMedicine. 46:184-192.

  • Semper, C., Stogios, P., Meziane-Cherif, D., Evdokimova, E., Courvalin, P., Savchenko, A. 2020. Structural characterization of aminoglycoside 4'-O-adenylyltransferase ANT(4')-IIb from Pseudomonas aeruginosa. Protein Sci. 29(3):758-767.

  • Andersson, D. I., Balaban, N. Q., Baquero, F., Courvalin, P., Glaser, P., Gophna, U., Kishony, R., Molin, S., Tønjum, T. 2020. Antibiotic resistance: turning evolutionary principles into clinical reality.

  • FEMS Microbiol Rev. 44(2):171-188.

  • Maillard, J.Y., Bloomfield, S.F., Courvalin, P., Essack, S.Y., Gandra, S., Gerba, C.P., Rubino, J.R., Scott, E. A. 2020. Reducing antibiotic prescribing and addressing the global problem of antibiotic resistance by targeted hygiene in the home and everyday life settings: A position paper. Am J Infect Control. 48(9):1090-1099. 

  • Bodendoerfer, E., Marchesi, M., Imkamp, F., Courvalin, P., Böttger, E. C., Mancini, S. 2020. Co-occurrence of aminoglycoside and β-lactam resistance mechanisms in aminoglycoside- non-susceptible Escherichia coli isolated in the Zurich area, Switzerland. Int J Antimicrob Agents. 56(1):106019.

  • Mancini, S., Röthlin, K., Bodendoerfer, E., Herren, S., Kolesnik-Goldmann, N., Courvalin, P., Zbinden, R., Böttger, E.C. 2020. Tentative breakpoints and areas of technical uncertainty for early reading automated disc diffusion for Enterobacterales. J Antimicrob Chemother. 75(6):1495-1505.

  • Dubreuil, L.; Members of the CA-SFM 2019. 2020. Improvement of a disk diffusion method for antibiotic susceptibility testing of anaerobic bacteria. French recommendations revisited for 2020. Anaerobe. 64:102213.

  • Mancini, S., Bodendoerfer, E., Kolensnik-Goldmann, N., Herren S, Röthlin K, Courvalin, P., Böttger, E.C. 2020. Evaluation of standardized automated rapid antimicrobial susceptibility testing of Enterobacterales-containing blood cultures: a proof-of-principle study. J Antimicrob Chemother. 75(11):3218-3229.

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